Todd Eckroat, Ph.D.

Todd Eckroat, Ph.D.
Assistant Professor, Chemistry
37 Hammermill

Mailing Address:
ERIE PA 16563


  • Post-Doctoral Research Associate, 2014-2015
  • University of Note Dame, Notre Dame, IN

Teaching Specialties

  • Organic Chemistry
  • Biochemistry
  • Medicinal Chemistry

Synthesis of heterocyclic compounds and natural products; Synthesis and development of isatin-based acetylcholinesterase and butyrylcholinesterase inhibitors relevant for Alzheimer's Disease

Evaluation of N-Alkyl Isatins and Indoles as Acetylcholinesterase and Butyrylcholinesterase Inhibitors, Journal of Enzyme Inhibition and Medicinal Chemistry - December 7, 2023
Collaborators: Kaitlyn Alcorn, Student Author; Isabelle Oberhauser, Student Author; Matthew Politeski, Student Author

Selective butyrylcholinesterase inhibition by isatin dimers and 3-indolyl-3-hydroxy-2-oxindole dimers, Bioorganic and Medicinal Chemistry Letters - October 25, 2022
Collaborator: Kristin Reiland, Student Author

Isatin-linked 4,4-dimethyl-5-methylene-4,5-dihydrothiazole-2-thiols for inhibition of acetylcholinesterase, Medicinal Chemistry Research - October 20, 2021
Collaborator: Sydney Davis, Student Author

The Type 9 Secretion System is Required for Flavobacterium johnsoniae Biofilm Formation, Frontiers in Microbiology - September 2, 2021
Collaborators: Camillus Greguske; David Hunnicutt, Corresponding Author

Merged Tacrine-Based, Multitarget-Directed Acetylcholinesterase Inhibitors 2015-Present: Synthesis and Biological Activity, International Journal of Molecular Sciences - August 19, 2020
Collaborators: Danielle Manross, Student Author; Seth Cowan, Student Author

Welcome to Fall semester! We’re happy to be back so to kick off the new season we are sharing this insightful post from Professor Todd Eckroat of Penn State Erie- The Behrend College., Teach the Mechanism - September 19, 2019

A novel hybrid of 6-chlorotacrine and metal-amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation, Chemical Science - July 23, 2013
Collaborators: A Kochi, Primary Author; K Green, Co-Author; A Mayhoub, Co-Author; M Lim, Co-Author; S Garneau-Tsodikova, Co-Author

Investigation of the role of linker moieties in bifunctional tacrine hybrids, Bioorganic & Medicinal Chemistry - June 15, 2013
Collaborators: K Green, Co-Author; R Reed, Co-Author; J Bornstein, Co-Author; S Garneau-Tsodikova, Co-Author

Amyloid-β probes: Review of structure-activity and brain-kinetics relationships., Beilstein Journal of Organic Chemistry - May 28, 2013
Collaborators: A Mayhoub, Co-Author; S Garneau-Tsodikova, Co-Author

Tacrine-mefenamic acid hybrids for inhibition of acetylcholinesterase, Medicinal Chemical Communications - March 9, 2011
Collaborators: J Bornstein, Primary Author; J Houghton, Co-Author; C Jones, Co-Author; K Green, Co-Author; S Garneau-Tsodikova, Co-Author

Ph D, Medicinal Chemistry, The University of Michigan

BS, Biology, The Pennsylvania State University

BS, Chemistry, The Pennsylvania State University